Page 32 - SaxoCell Annual Report 2021
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AlloCART
AlloCART, the project for the "Preclinical Development of Switchable UniCAR-T as well as
UniCAR-Treg" focuses on the development of a serial production of a cell type that
suppresses excessive immune responses in healthy humans. These so-called regulatory
T cells (Treg) are to be isolated and propagated from healthy donors. The Treg will be
SaxoCell Projects to the target tissue to locally suppress inflammatory responses.
equipped with novel 2-component adaptors (UniCAR technology) that promote docking
In particular, novel cell isolation and genetic modification techniques are used to
generate UniCAR Treg.
Project Manager: Prof. Dr. Martin Bornhäuser and Dr. Anke Fuchs
Project Partners: Helmholtz Center Dresden Rossendorf, University Hospital Dresden,
Technical University Dresden
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