Page 38 - SaxoCell Annual Report22/23
P. 38

Identification  and  characteri-
                                                                                    zation  of  human  regenerative
                                                                                    fibroblasts.  Skin  is  taken  from
                                                                                    healthy  human  donors  by
                                                                                    biopsy   and   the   different
                                                                                    fibroblast  subpopulations  are
                                                                                    identified  by  single-cell  se-
                                                                                    quencing  and  compared  with
                                                                                    existing  data  sets.  The  fibro-
                                                                                    blast  subpopulations  are  then
                                                                                    divided  into  functional  groups
                                                                                    based  on  their  properties  (in-
                                                                                    cluding  surface  markers).  The
                                                                                    regenerative  properties  of  the
                                                                                    corresponding populations will
                                                                                    then  be  tested  and  verified  in
                                                                                    preclinical models.

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