Page 48 - SaxoCell Annual Report22/23

T cell

Adapter CAR

Target molecule

Schematic representation of the gated positive (GP) and gated
Target antigen inhibitory (GI) Adapter CAR (RevCAR) platform for tumor cell killing
and modulation of the tumor microenvironment. T cells are genetically
modified to express adapter CARs. These GP/GI-CAR T cells require a
Tumor cell target molecule to recognize and kill tumor cells that present a specific
target antigen (e.g., tumor-associated antigens or "immune checkpoint"
molecules).

So far, we have successfully demonstrated in cell culture experiments that GP/GI-CAR-T cells in
combination with the new TMs can specifically and efficiently destroy antigen-expressing tumor
cells. The activity of GP/GI-CAR-T cells is strictly dependent on the presence of appropriate TMs.

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