Page 46 - SaxoCell Annual Report22/23
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Therefore, a project amendment of the ECP - CAR project was created. The project will be used to
prospectively apply an ECP procedure prior to CAR-T cell administration by generating data and
elucidating the exact mechanism of action of ECP. Samples from different time points will be taken
from patients currently treated in the clinic and subjected to ECP treatment. Cell populations,
proliferation of T cells, apoptosis and cytotoxic competence of CAR-T cells will be investigated.
Procedure to study the immunomodulatory effect of ECP treatment before and during CAR-T cell therapy
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